Phylogeny of Spanish swine influenza viruses isolated from respiratory disease outbreaks and evolution of swine influenza virus within an endemically infected farm.
Identifieur interne : 000210 ( Main/Exploration ); précédent : 000209; suivant : 000211Phylogeny of Spanish swine influenza viruses isolated from respiratory disease outbreaks and evolution of swine influenza virus within an endemically infected farm.
Auteurs : Gerard E. Martín-Valls [Espagne] ; Meritxell Simon-Grifé [Espagne] ; Sander Van Boheemen [Pays-Bas] ; Miranda De Graaf [Pays-Bas] ; Theo M. Bestebroer [Pays-Bas] ; Núria Busquets [Espagne] ; Margarita Martín [Espagne] ; Jordi Casal [Espagne] ; Ron A M. Fouchier [Pays-Bas] ; Enric Mateu [Espagne]Source :
- Veterinary microbiology [ 1873-2542 ] ; 2014.
Descripteurs français
- KwdFr :
- Alignement de séquences (MeSH), Animaux (MeSH), Données de séquences moléculaires (MeSH), Espagne (MeSH), Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (virologie), Maladies des porcs (virologie), Phylogenèse (MeSH), Similitude de séquences d'acides nucléiques (MeSH), Sous-type H1N1 du virus de la grippe A (classification), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sous-type H1N2 du virus de la grippe A (classification), Sous-type H1N2 du virus de la grippe A (génétique), Sous-type H1N2 du virus de la grippe A (isolement et purification), Sous-type H3N2 du virus de la grippe A (classification), Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (isolement et purification), Suidae (MeSH), Séquence nucléotidique (MeSH), Virus de la grippe A (classification), Virus de la grippe A (génétique), Virus de la grippe A (isolement et purification), Virus recombinants (classification), Virus recombinants (génétique), Virus recombinants (isolement et purification), Évolution moléculaire (MeSH).
- MESH :
- génétique : Sous-type H1N1 du virus de la grippe A, Sous-type H1N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Virus de la grippe A, Virus recombinants.
- isolement et purification : Sous-type H1N1 du virus de la grippe A, Sous-type H1N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Virus de la grippe A, Virus recombinants.
- médecine vétérinaire : Infections à Orthomyxoviridae.
- virologie : Infections à Orthomyxoviridae, Maladies des porcs.
- classification : Alignement de séquences, Animaux, Données de séquences moléculaires, Espagne, Phylogenèse, Similitude de séquences d'acides nucléiques, Sous-type H1N1 du virus de la grippe A, Sous-type H1N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Suidae, Séquence nucléotidique, Virus de la grippe A, Virus recombinants, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals (MeSH), Base Sequence (MeSH), Evolution, Molecular (MeSH), Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza A Virus, H1N2 Subtype (classification), Influenza A Virus, H1N2 Subtype (genetics), Influenza A Virus, H1N2 Subtype (isolation & purification), Influenza A Virus, H3N2 Subtype (classification), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (isolation & purification), Influenza A virus (classification), Influenza A virus (genetics), Influenza A virus (isolation & purification), Molecular Sequence Data (MeSH), Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Phylogeny (MeSH), Reassortant Viruses (classification), Reassortant Viruses (genetics), Reassortant Viruses (isolation & purification), Sequence Alignment (MeSH), Sequence Homology, Nucleic Acid (MeSH), Spain (MeSH), Swine (MeSH), Swine Diseases (virology).
- MESH :
- classification : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H1N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus, Reassortant Viruses.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H1N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus, Reassortant Viruses.
- isolation & purification : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H1N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus, Reassortant Viruses.
- veterinary : Orthomyxoviridae Infections.
- virology : Orthomyxoviridae Infections, Swine Diseases.
- Animals, Base Sequence, Evolution, Molecular, Molecular Sequence Data, Phylogeny, Sequence Alignment, Sequence Homology, Nucleic Acid, Spain, Swine.
Abstract
In the present study, outbreaks of respiratory disease were investigated for the presence of swine influenza virus (SIV). In 14 cases the circulating SIV strains were isolated, fully sequenced and compared with other known SIVs. The viruses causing the outbreaks belonged to the H1N1 (including human pandemic H1N1), H3N2 and H1N2 subtypes. In 11/14 cases the phylogenetic analyses indicated the occurrence of probable reassortment events. In the second part of the study, the genetic evolution of H1N1 SIV was assessed in a longitudinal study in closed groups of pigs over six months. Sequencing of the 22 isolates indicated co-circulation of two different variants for the same virus, as well as the emergence of SIV reassortants at certain time-points. These results indicate that reassortment events in SIV are common, and point towards the need for a better understanding of the epidemiology of SIV, particularly in endemic farms.
DOI: 10.1016/j.vetmic.2014.02.031
PubMed: 24685238
Affiliations:
- Espagne, Pays-Bas
- Catalogne, Hollande-Méridionale
- Barcelone, Rotterdam
- Université autonome de Barcelone
Links toward previous steps (curation, corpus...)
Le document en format XML
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Electronic address: marga.martin@uab.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Casal, Jordi" sort="Casal, Jordi" uniqKey="Casal J" first="Jordi" last="Casal">Jordi Casal</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. 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Electronic address: r.fouchier@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mateu, Enric" sort="Mateu, Enric" uniqKey="Mateu E" first="Enric" last="Mateu">Enric Mateu</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. Electronic address: enric.mateu@uab.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24685238</idno><idno type="pmid">24685238</idno><idno type="doi">10.1016/j.vetmic.2014.02.031</idno><idno type="wicri:Area/Main/Corpus">00211</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00211</idno><idno type="wicri:Area/Main/Curation">000211</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000211</idno><idno type="wicri:Area/Main/Exploration">000211</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Phylogeny of Spanish swine influenza viruses isolated from respiratory disease outbreaks and evolution of swine influenza virus within an endemically infected farm.</title><author><name sortKey="Martin Valls, Gerard E" sort="Martin Valls, Gerard E" uniqKey="Martin Valls G" first="Gerard E" last="Martín-Valls">Gerard E. Martín-Valls</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: g.e.martinvalls@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Simon Grife, Meritxell" sort="Simon Grife, Meritxell" uniqKey="Simon Grife M" first="Meritxell" last="Simon-Grifé">Meritxell Simon-Grifé</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: meritxell.simon@hipra.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Van Boheemen, Sander" sort="Van Boheemen, Sander" uniqKey="Van Boheemen S" first="Sander" last="Van Boheemen">Sander Van Boheemen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam, The Netherlands. Electronic address: s.vanboheemen@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam, The Netherlands. Electronic address: m.degraaf@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M" last="Bestebroer">Theo M. Bestebroer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam, The Netherlands. Electronic address: t.bestebroer@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Busquets, Nuria" sort="Busquets, Nuria" uniqKey="Busquets N" first="Núria" last="Busquets">Núria Busquets</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: nuria.busquets@cresa.uab.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Martin, Margarita" sort="Martin, Margarita" uniqKey="Martin M" first="Margarita" last="Martín">Margarita Martín</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. Electronic address: marga.martin@uab.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Casal, Jordi" sort="Casal, Jordi" uniqKey="Casal J" first="Jordi" last="Casal">Jordi Casal</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. Electronic address: jordi.casal@uab.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam, The Netherlands. Electronic address: r.fouchier@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mateu, Enric" sort="Mateu, Enric" uniqKey="Mateu E" first="Enric" last="Mateu">Enric Mateu</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. Electronic address: enric.mateu@uab.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author></analytic><series><title level="j">Veterinary microbiology</title><idno type="eISSN">1873-2542</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Base Sequence (MeSH)</term><term>Evolution, Molecular (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (classification)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza A Virus, H1N2 Subtype (classification)</term><term>Influenza A Virus, H1N2 Subtype (genetics)</term><term>Influenza A Virus, H1N2 Subtype (isolation & purification)</term><term>Influenza A Virus, H3N2 Subtype (classification)</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza A Virus, H3N2 Subtype (isolation & purification)</term><term>Influenza A virus (classification)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (isolation & purification)</term><term>Molecular Sequence Data (MeSH)</term><term>Orthomyxoviridae Infections (veterinary)</term><term>Orthomyxoviridae Infections (virology)</term><term>Phylogeny (MeSH)</term><term>Reassortant Viruses (classification)</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (isolation & purification)</term><term>Sequence Alignment (MeSH)</term><term>Sequence Homology, Nucleic Acid (MeSH)</term><term>Spain (MeSH)</term><term>Swine (MeSH)</term><term>Swine Diseases (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences (MeSH)</term><term>Animaux (MeSH)</term><term>Données de séquences moléculaires (MeSH)</term><term>Espagne (MeSH)</term><term>Infections à Orthomyxoviridae (médecine vétérinaire)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Maladies des porcs (virologie)</term><term>Phylogenèse (MeSH)</term><term>Similitude de séquences d'acides nucléiques (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (classification)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>Sous-type H1N2 du virus de la grippe A (classification)</term><term>Sous-type H1N2 du virus de la grippe A (génétique)</term><term>Sous-type H1N2 du virus de la grippe A (isolement et purification)</term><term>Sous-type H3N2 du virus de la grippe A (classification)</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term><term>Sous-type H3N2 du virus de la grippe A (isolement et purification)</term><term>Suidae (MeSH)</term><term>Séquence nucléotidique (MeSH)</term><term>Virus de la grippe A (classification)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (isolement et purification)</term><term>Virus recombinants (classification)</term><term>Virus recombinants (génétique)</term><term>Virus recombinants (isolement et purification)</term><term>Évolution moléculaire (MeSH)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H1N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H1N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H1N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H1N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H1N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Maladies des porcs</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>Evolution, Molecular</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Sequence Alignment</term><term>Sequence Homology, Nucleic Acid</term><term>Spain</term><term>Swine</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Alignement de séquences</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Espagne</term><term>Phylogenèse</term><term>Similitude de séquences d'acides nucléiques</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H1N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Suidae</term><term>Séquence nucléotidique</term><term>Virus de la grippe A</term><term>Virus recombinants</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the present study, outbreaks of respiratory disease were investigated for the presence of swine influenza virus (SIV). In 14 cases the circulating SIV strains were isolated, fully sequenced and compared with other known SIVs. The viruses causing the outbreaks belonged to the H1N1 (including human pandemic H1N1), H3N2 and H1N2 subtypes. In 11/14 cases the phylogenetic analyses indicated the occurrence of probable reassortment events. In the second part of the study, the genetic evolution of H1N1 SIV was assessed in a longitudinal study in closed groups of pigs over six months. Sequencing of the 22 isolates indicated co-circulation of two different variants for the same virus, as well as the emergence of SIV reassortants at certain time-points. These results indicate that reassortment events in SIV are common, and point towards the need for a better understanding of the epidemiology of SIV, particularly in endemic farms. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">24685238</PMID><DateCompleted><Year>2014</Year><Month>07</Month><Day>11</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2542</ISSN><JournalIssue CitedMedium="Internet"><Volume>170</Volume><Issue>3-4</Issue><PubDate><Year>2014</Year><Month>Jun</Month><Day>04</Day></PubDate></JournalIssue><Title>Veterinary microbiology</Title><ISOAbbreviation>Vet. Microbiol.</ISOAbbreviation></Journal><ArticleTitle>Phylogeny of Spanish swine influenza viruses isolated from respiratory disease outbreaks and evolution of swine influenza virus within an endemically infected farm.</ArticleTitle><Pagination><MedlinePgn>266-77</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vetmic.2014.02.031</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0378-1135(14)00121-7</ELocationID><Abstract><AbstractText>In the present study, outbreaks of respiratory disease were investigated for the presence of swine influenza virus (SIV). In 14 cases the circulating SIV strains were isolated, fully sequenced and compared with other known SIVs. The viruses causing the outbreaks belonged to the H1N1 (including human pandemic H1N1), H3N2 and H1N2 subtypes. In 11/14 cases the phylogenetic analyses indicated the occurrence of probable reassortment events. In the second part of the study, the genetic evolution of H1N1 SIV was assessed in a longitudinal study in closed groups of pigs over six months. Sequencing of the 22 isolates indicated co-circulation of two different variants for the same virus, as well as the emergence of SIV reassortants at certain time-points. These results indicate that reassortment events in SIV are common, and point towards the need for a better understanding of the epidemiology of SIV, particularly in endemic farms. </AbstractText><CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martín-Valls</LastName><ForeName>Gerard E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: g.e.martinvalls@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simon-Grifé</LastName><ForeName>Meritxell</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: meritxell.simon@hipra.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Boheemen</LastName><ForeName>Sander</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam, The Netherlands. Electronic address: s.vanboheemen@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Graaf</LastName><ForeName>Miranda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam, The Netherlands. Electronic address: m.degraaf@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bestebroer</LastName><ForeName>Theo M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam, The Netherlands. Electronic address: t.bestebroer@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Busquets</LastName><ForeName>Núria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Electronic address: nuria.busquets@cresa.uab.cat.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martín</LastName><ForeName>Margarita</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. Electronic address: marga.martin@uab.cat.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casal</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. Electronic address: jordi.casal@uab.cat.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fouchier</LastName><ForeName>Ron A M</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Department of Virology, Erasmus Medical Center, Erasmus University, 3015GE Rotterdam, The Netherlands. Electronic address: r.fouchier@erasmusmc.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mateu</LastName><ForeName>Enric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Departament de Sanitat i Anatomia animals, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. Electronic address: enric.mateu@uab.cat.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>JX908030</AccessionNumber><AccessionNumber>JX908031</AccessionNumber><AccessionNumber>JX908032</AccessionNumber><AccessionNumber>JX908033</AccessionNumber><AccessionNumber>JX908034</AccessionNumber><AccessionNumber>JX908035</AccessionNumber><AccessionNumber>JX908036</AccessionNumber><AccessionNumber>JX908037</AccessionNumber><AccessionNumber>JX908038</AccessionNumber><AccessionNumber>JX908039</AccessionNumber><AccessionNumber>JX908040</AccessionNumber><AccessionNumber>JX908041</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vet Microbiol</MedlineTA><NlmUniqueID>7705469</NlmUniqueID><ISSNLinking>0378-1135</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="Y">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057221" MajorTopicYN="N">Influenza A Virus, H1N2 Subtype</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="Y">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016865" MajorTopicYN="N">Reassortant Viruses</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012689" MajorTopicYN="N">Sequence Homology, Nucleic Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013553" MajorTopicYN="N">Swine Diseases</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Influenza</Keyword><Keyword MajorTopicYN="N">Reassortment</Keyword><Keyword MajorTopicYN="N">SIV emergence</Keyword><Keyword MajorTopicYN="N">Swine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>09</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>02</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>7</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24685238</ArticleId><ArticleId IdType="pii">S0378-1135(14)00121-7</ArticleId><ArticleId IdType="doi">10.1016/j.vetmic.2014.02.031</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li><li>Pays-Bas</li></country><region><li>Catalogne</li><li>Hollande-Méridionale</li></region><settlement><li>Barcelone</li><li>Rotterdam</li></settlement><orgName><li>Université autonome de Barcelone</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Martin Valls, Gerard E" sort="Martin Valls, Gerard E" uniqKey="Martin Valls G" first="Gerard E" last="Martín-Valls">Gerard E. Martín-Valls</name></region><name sortKey="Busquets, Nuria" sort="Busquets, Nuria" uniqKey="Busquets N" first="Núria" last="Busquets">Núria Busquets</name><name sortKey="Casal, Jordi" sort="Casal, Jordi" uniqKey="Casal J" first="Jordi" last="Casal">Jordi Casal</name><name sortKey="Martin, Margarita" sort="Martin, Margarita" uniqKey="Martin M" first="Margarita" last="Martín">Margarita Martín</name><name sortKey="Mateu, Enric" sort="Mateu, Enric" uniqKey="Mateu E" first="Enric" last="Mateu">Enric Mateu</name><name sortKey="Simon Grife, Meritxell" sort="Simon Grife, Meritxell" uniqKey="Simon Grife M" first="Meritxell" last="Simon-Grifé">Meritxell Simon-Grifé</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Boheemen, Sander" sort="Van Boheemen, Sander" uniqKey="Van Boheemen S" first="Sander" last="Van Boheemen">Sander Van Boheemen</name></region><name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M" last="Bestebroer">Theo M. Bestebroer</name><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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